Why do certain students thrive when facing adversity while others languish? In the mindset theory, growth mindset is opposed to fixed mindset, and could explain why some people fulfil their potential and others do not. With the COVID pandemic dragging on, having a growth mindset may be even more critical. For students who are able to set their own learning goals, elaborate learning strategies, and master their progress, the disruptive experience of school closing may be enriching. For students who are used to being led in their learning and who have little taste for steering their learning on their own, the experience may be devastating. This PISA in Focus analyses how growth mindset is related to the performance and well-being of 15-year-old students, and its potential implications in terms of equity.