Collaboration between governments, civil society and corporations is acquiring increasing importance in the international agenda as a solution to the complex problems currently affecting our societies. It has become clear that issues such as climate change, persistent poverty, increasing inequality, social exclusion and other major current challenges cannot be tackled by a single sector alone. Given this reality, it is encouraging to see that more and more initiatives featuring various forms of collaboration are being enacted to tackle major social issues. However, despite progress, there is limited knowledge of these initiatives in different countries. This study aims at filling this gap by examining in Mexico how foundations and federal government (FG) departments and agencies have been engaging with each other.