This follow-up to the 2001 OECD Territorial Review of Bergamo monitors progress over the past 15 years and reassesses the main development challenges the region faces. Globalisation has intensified international competition in Bergamo’s traditional manufacturing sector, and the global financial crisis has exacerbated some of the structural weaknesses of Bergamo’s traditional industrial sectors. The region needs to upgrade production processes to generate more added value in economic activities to remain competitive. The review offers recommendations to help Bergamo transition to higher value-added and more technologically intensive activities. In particular, it calls for: a development plan supported by all local actors; a strategy for improving the skills of the adult population through education and training programmes; stimulating innovation systems; attracting foreign direct investment; and, finally, strategies for boosting the competitiveness of small and medium-sized enterprises.