This report investigates the development of the blockchain ecosystem in Italy, against the background of the SME and entrepreneurship structure and trends in the country. The report analyses in particular the characteristics and trends of companies introducing blockchain-based services in the Italian market, opportunities and challenges to their business development, sectors and firms being targeted, and relevance for enhancing digitalisation and productivity in the SME population at large. The report also illustrates recent trends in regulation and policy, and provides policy recommendations.