This is the second in a series of three reports that explore how science was mobilised in response to the COVID-19 pandemic. The focus is on science for policy – research agenda setting, scientific advice and public communication and engagement. The report includes recommendations and options for policy action to improve the resilience of national science systems and their capacity to cooperate internationally in response to crises. The context in each country is different, as illustrated by the many case studies included in the report, and so the priority attached to these recommendations and the specific details of how they might be implemented will vary. They are provided as an overall framework for science policymakers and other actors, including research funders and research providers, to consider.