This paper provides a regional analysis of how governments in Latin America and the Caribbean (LAC) leverage trade and investment policies and agreements to promote responsible business conduct (RBC). It builds on a mapping of over 450 trade and investment agreements, takes stock of relevant policies and practices in nine LAC countries, and examines the role National Contact Points for Responsible Business Conduct (NCPs) play in this regard. The paper identifies key trends, challenges and opportunities and sets out policy considerations to enhance the uptake of RBC through trade and investment with the support of LAC NCPs.