Russia’s invasion of Ukraine has had devastating impacts on the people of Ukraine. The consequences stemming from the war have imperilled the world's economic recovery from the COVID-19 pandemic and are reshaping and disrupting global supply chains, with ramifications for food security, energy, and other critical sectors. The war has also put a spotlight on the role of businesses operating in the region, facing heightened challenges in maintaining responsible business conduct (RBC) in high-risk settings. In this highly dynamic context, businesses should consider risks of being linked or contributing to adverse impacts on people, planet and society via their operations or business relationships. This note takes stock of how Russia’s war against Ukraine has had an impact on and shaped considerations for RBC.