The SIGI 2021 Regional Report for Africa provides regional analysis on how discriminatory social institutions, such as formal and informal laws, social norms and practices, continue to constrain women’s empowerment and restrict their access to opportunities and rights. It gives new evidence on the impact of these discriminatory social institutions on three key dimensions of women’s empowerment across the region: their physical integrity, their economic situation and their political voice, leadership and agency. The report provides regional as well as thematic policy recommendations that aim to transform gender norms, promote women’s empowerment and build a truly inclusive society, especially in the current context of the coronavirus (COVID-19) pandemic.