The aim of the OECD (Quantitative) Structure-Activity Relationship ((Q)SAR) Assessment Framework (QAF) is to provide a systematic and harmonised framework for the regulatory assessment of (Q)SAR models, predictions and results based on multiple predictions. The QAF is meant to be applicable (Q)SARs, irrespective of the modelling technique used to build the model, the predicted endpoint, and the intended regulatory purpose. The updated second edition includes a reporting format for (Q)SAR results that rely on multiple predictions. The (Q)SAR Result Reporting Format (QRRF) was created to address an identified gap in the first edition of the QAF and is designed to increase confidence in using (Q)SAR results for regulatory application. The primary audience of this document is regulatory authorities and their stakeholders. In addition, any other (Q)SAR user is encouraged to refer to the QAF when using (Q)SARs for regulatory purposes.